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Fig. 3 | Genome Biology

Fig. 3

From: NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

Fig. 3

NSD2 EK-related B to A compartment switches and shifts correlate with gene expression changes. a Scatter plot demonstrating strategy for calling 6 categories of compartment switches and shifts (A to B, and B to A compartment switches; A to less A, A to more A, B to less B, and B to more B compartment shifts). b Bar plot showing number of compartment switches and shifts for each cell line from NSD2 Low to NSD2 High. c Correlation boxplots of compartment cscore and gene expression changes (abs(L2FC) > 0.32, p-value 0.05) for each cell line. d Volcano plots demonstrating differentially expressed genes (abs(L2FC) > 0.32, p-value < 0.05) highlighted by compartment switch or shift (A to less A, A to B, B to more B, or stable). e KEGG 2021 pathway enrichment analysis of genes differentially expressed (L2FC < −0.32, p-value < 0.05) at B to A compartment switches or A to more A and B to less B compartment shifts per cell line

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