Fig. 1

NSD2 EK drives A/B compartment reorganization. a Schematic demonstrating overall study design. b PCA of A/B compartment calls with Cscore. c Pie chart showing numbers of A and B compartment calls for each cell line in NSD2 Low and High cell lines. d Bar plot showing number of compartment switches for each cell line from NSD2 Low to NSD2 High. e Venn diagram showing overlap of switching compartments between three B-ALL cell lines, B to A and A to B switches (left and right respectively). f Heatmap representation of the cscore (first eigenvector (PC1) of the correlation matrix) for genomic bins undergoing compartment switches in at least 2 of the 3 cell lines due to NSD2 EK. g IGV tracks of an example of B to A compartment switch shared by all three cell lines at the NEO1 locus (left). IGV tracks of an example of a B to A compartment switch specific to RS4;11 cell line at the PRDM8 and FGF5 locus (right)