Fig. 2
From: CRISPR screens identify gene targets at breast cancer risk loci
CRISPR activation and suppression screens identify BC risk genes that regulate tumor growth in mice. A Experimental approach. B Summary of hits from the in vivo screens. C Proliferation in 3D cultures of WT or MEKDD expressing B80-T5 cells following suppression of DUSP4 expression. D DUSP4 protein levels following expression of MEKDD. E Phosphorylation of ERK, JNK and p38 following MEK inhibition. F The effect of MEK inhibitors on proliferation in DUSP4 ko cells