Fig. 1
From: CRISPR screens identify gene targets at breast cancer risk loci
CRISPR activation and suppression screens identify BC risk genes that regulate proliferation in 2D, 3D. A Pie chart showing locations of CCVs at 205 BC risk signals identified by GWAS. B Classes of genes selected for functional CRISPR screens. INQ_1 – high-confidence INQUISIT predictions; INQ_2—moderate-confidence INQUISIT predictions; TWAS – identified by transcriptome wide association studies and eQTL studies. C Experimental approach. D Summary of results from 2 and 3D proliferation screens. Known driver gene annotations were from [3]