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Fig. 5 | Genome Biology

Fig. 5

From: Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects

Fig. 5

TUBA4A is evolutionarily conserved across species and highly expressed in human oocytes. a Distribution and evolutionary conservation of TUBA4A mutations. Mutations identified in this study are marked as colored lollipop. The conservation analysis of the mutant amino acids is indicated by the alignment of five mammalian species and mutant residues are shown in red. b Violin plot showing the expression dynamics of TUBA4A during folliculogenesis. c The relative expression of TUBA4A mRNA in different stages of human oocytes, embryos, and several somatic tissues and normalized to ACTIN mRNA. The bars show the mean of three separate measurements, and error bars denote standard deviations

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Genome Biology

ISSN: 1474-760X

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