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Fig. 2. | Genome Biology

Fig. 2.

From: The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

Fig. 2.

Analysis of the ratio of P323:L323 (light blue) and D614:G614 (blue) in 377 patient samples between January 2020 and May 2020 in the A UK and B worldwide (a ratio of 1.00= L323/G614 dominant and the violin plot indicates the number of samples). SARS-CoV-2 sequence was obtained from nasopharyngeal swabs from 377 hospitalized patients. The width of the violin plot indicates the number of samples/patients with the frequency on the y-axis. The data shows the transition from P323L and D614G over time in the minor variant genomes, such that by April 2020 in the UK, the L323 and G614 substitutions were part of the dominant viral genome sequence and by May 2020, there was no evidence of P323 and D614 at the dominant level. The y-axis (variation frequency) is in the direction of P323 to L323 and D614 to G614, such that a viral population with 100% L323 or G614 would be shown with a variation frequency of 1.00. Likewise, if there is a variation frequency of 0.00, this would mean that there was a viral population with 100% P323 or D614

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