Fig. 5

The length of an insertion and deletion impacts Kir2.1 surface expression. A Impact of varying the length of deletion on surface expression mapped onto the M1 transmembrane alpha helix and slide helix colored from low-to-high surface expression, red-to-white-to-blue, respectively. B Surface scores for the slide-helix position with varying lengths of deletions colored with increasing hue for increasing (or decreasing) length. 1-2 amino acid deletions are tolerated while 3 amino acids result in substantially less surface expression. C Impact of varying the length of deletion (top) and insertion (bottom) on surface expression mapped onto three of the immunoglobulin beta sheets colored from low-to-high surface expression, red-to-white-to-blue, respectively. D Surface scores for the beta sheet positions, with increasing indel lengths colored with darker hues. The sequences of the segment connecting βD and βH are removed to focus on β sheet