Fig. 5

Model for the effects of C4A brain expression on childhood brain structure. The effects of increased C4A GREx on reduced entorhinal cortex volume in childhood are dissociated from the effects of genome-wide polygenic risk for schizophrenia. Reduced entorhinal cortex surface area in childhood is associated with higher rates of youth-reported psychotic-like experiences (PLEs) in early adolescence, as well as greater severity of events. Note: Image under “psychotic-like experiences” taken from the Prodromal Questionnaire Brief Version (PQ-B) to assess the severity of distress associated with psychotic-like events