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Fig. 2 | Genome Biology

Fig. 2

From: Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Fig. 2

Phenome-wide association between C4A GREx and cognitive, behavioral phenotypes in the ABCD cohort. A The relationship between C4A GREx and 145 phenotypes was tested in the multi-ancestry cohort (N’s per phenotype ~ 6000). Increased genetically regulated expression of C4A was associated with lower scores on the UPPS-P Impulsive Behavior Scale (Lynam, [27]) lack of premeditation/planning subscale (FDR-corrected P = 0.004). Phenotypes are grouped into broad categories by color. Negative or positive associations with C4A GREx are indicated by the direction of arrows. The FDR-based threshold for phenome-wide significance is indicated by the red dashed line. B Association (absolute 𝛽 ± standard error) between C4A GREx and each of the three psychosis variables investigated (binary case/control, PQ-B number PQ-B severity) in the multi-ancestry cohort (i.e., “ALL” youth [as in top panel]), as well as within each ancestry and sex separately. See Additional file 1: Table S3 for the regression model summary statistics. The results by ancestry and sex are shown in Additional file 2: Figs. S3-S8

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