Fig. 2

Conservation of genomic imprinting in rat and mouse. a Heatmap of parental expression ratios in rat and mouse Epi and EPC cells. Genes previously identified as imprinted in human are indicated with an asterisk. b Heatmap of allele-specific DNAme levels over DMRs associated with imprinted genes in a. The relative position of DMRs is included. DMRs that also show parent-specific methylation in human are indicated with an asterisk. c–d Rat and mouse genome browser screenshots of the Kcnq1 locus. Figure legend as in Fig. 1c, with the addition of DNA methylation information. The average DNAme level over each CpG is shown as individual bar plots, and CpGs covered by at least 1 allele-specific read (Epi, EPC) or 5 reads (gametes) are shown. Pink indicates methylation of both alleles. Rat DMRs are included. In rat, a paternally expressed unannotated antisense ncRNA is expressed from the gene body of Kcnq1. The position of the putative Kcnq1ot1 imprinted CGI promoter is indicated by a dashed box. d The mouse Kcnq1 locus is shown for comparison