Fig. 8
From: BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data
Comparisons of different locus-to-gene prioritization methods. Precision vs. recall is shown for several representative methods including closest footprint, cS2G, L2G, BIGKnock Effector genes (BK-Effector), BIGKnock Effector genes and genes at BIGKnock significant loci with only one significant gene (BK-Effector+1), as well as combination of BIGKnock and cS2G (BK-cS2G) and L2G (BK-L2G). a Gold standard and Backman effector dataset including 221 positive genes at BIGKnock significant loci. The negative genes include 3255 genes located within the 1Mb loci containing the 221 positive genes; b Forgetta et al. gene set including 55 positive genes at BIGKnock significant loci. The negative genes include 860 genes located at 1Mb loci containing the 55 positive genes