Fig. 2
From: BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data
Applications to UK Biobank binary traits (1). a–d, Manhattan plots for BIGKnock, Scatter plot of W knockoff statistics (BIGKnock) vs. \(-\text {log}_{10}\)(p value) (GeneScan3D), and Scatter plot of the number of significant genes per locus between conventional GeneScan3D and BIGKnock are shown for a hypertension, b coronary artery disease, c asthma, and d type 2 diabetes. The dashed lines in the left and middle panels show the significance thresholds defined by Bonferroni correction (for p-values) and by false discovery rate (FDR; for W statistic)