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Fig. 4 | Genome Biology

Fig. 4

From: An overview of DNA methylation-derived trait score methods and applications

Fig. 4

Cellular heterogeneity and its effects on DNAm measurements in bulk tissue. All scenarios show the same difference in DNAm between healthy and diseased samples. The DNAm differences between healthy and disease samples can reflect increased DNAm associated with disease (A, C, and lymphocytes in D) or cell-type proportion differences associated with disease status (B, D). Recreated with BioRender.com and inspired by Holbrook et al. [96]

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