Fig. 1
From: An overview of DNA methylation-derived trait score methods and applications
Methylation profile scores (MPS). a Sources of variability in DNAm measurements that inform the signal captured by scoring approaches. b Types of discovery cohort samples and their uses for the development of MPS. c Disease timeline: utility of DNAm scores depends on when blood is sampled. Created with BioRender.com. MPS, methylation profile score; PGS, polygenic score; mQTLs, methylation quantitative trait loci