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Fig. 5 | Genome Biology

Fig. 5

From: β-actin mediated H3K27ac changes demonstrate the link between compartment switching and enhancer-dependent transcriptional regulation

Fig. 5

Switching compartments show significant changes in the Activity and Contact frequency of enhancers with their target promoters. a Scatterplots showing change in log2(Activity) of unique enhancers between β-actin KO and WT cells and MEFs and ESCs. Only enhancers linked to differentially expressed genes are shown for each compartment. Each dot represents a single unique enhancer. b Scatterplots showing change in log2(Contact) of all enhancers with their promoters between β-actin KO and WT cells and MEFs and ESCs. Only enhancers linked to differentially expressed genes are shown for each compartment. Since each enhancer can interact with multiple genes, each dot represents an enhancer-promoter contact rather than a single unique enhancer. c (i) Bar plots showing the number of enhancers gained or lost during MEF to ESC reprogramming under assumptions of constant Activity or Contact. Only enhancers linked to differentially expressed genes are shown: (ii) bar plots showing the number of enhancers gained or lost upon β-actin loss under assumptions of constant Activity or Contact

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