Fig. 4From: Enhanced RNA knockdown efficiency with engineered fusion guide RNAs that function with both CRISPR-CasRx and hammerhead ribozymeEvaluation of CCRS knockdown specificity. Knockdown of Rluc was evaluated with the fusion guides of CCRS containing single mismatches at varying positions across the antisense sequence. Data are expressed as the mean ± SD. Each experiment was performed in triplicate five independent times. Each error bar indicates the variation between the means of five independent experiments. *p value < 0.05, and **p value < 0.01, relative to the control using a two-tailed t-testBack to article page