Fig. 2

CCRS is capable of luciferase reporter transcript knockdown. a Schematic of the dual-luciferase reporter system used to evaluate RNA knockdown efficiency of CCRS. b Knockdown of Renilla luciferase (Rluc) using CCRS and other existing technologies. c Knockdown of Renilla luciferase (Rluc) using CCRS, CCRS-NLS, and CCRS-NES. NLS, nuclear localization signal. NES, nuclear export signal. Results are shown as the mean ± SD. Each experiment was performed in triplicate five independent times. *p value < 0.05, and **p value < 0.01, relative to the control using a two-tailed t-test