Fig. 1

HMM identifies 3 states from LB1 ChIP-seq datasets across 12 human cell types. A Simplified overview of progressive lineage restriction indicating some of the cell types represented in the atlas, shown from greatest (left) to least (right) developmental potential. B Example track view of LB1 enrichment and associated LADs in all 12 cell types assayed (representative replicate track shown). LAD states defined by HMM per cell type shown above each LB1 track. T1-LADs in dark purple; T2-LADs in light purple. Regions highlighted in gray span differential LB1/LAD regions between cell types. Y-axis indicated on the first track is consistent across all tracks shown. C LB1 occupancy per LAD state in all 12 cell types. T1-LADs (dark purple) are the most enriched and nonLADs (gray) are the least enriched for LB1. D LB1 occupancy measured 100 kb up- and downstream of T2-LAD boundaries with nonLADs and T1-LADs shows sharp distinction of LB1 signal between these features