Fig. 4
From: Accounting for cis-regulatory constraint prioritizes genes likely to affect species-specific traits
Changes in the expression of EDNRB in great apes. A Comparison of human-chimpanzee EDNRB ASE to within-human ASE from GTEx. Raw ASE ratios (as opposed to the value derived from DESeq2) are indicated by “ASE Ratio.” The human-chimpanzee ASE is significantly outside of the human ASE distribution. p-values are from the Mann-Whitney U test comparing the distribution of human population ASE to human-chimpanzee ASE. B Comparison to the fetal brain population ASE distribution. C ASE of EDNRB across time points in cortical organoids. Expression from the human allele is consistently higher than expression from the chimpanzee allele. D Plot showing the mean expression of EDNRB across chimpanzee and human cell clusters [37]. Expression in the radial glia cluster “RGCs early 2” cluster is significantly higher than in all chimpanzee clusters by Mann-Whitney U test (p < 10−16 for all comparisons). Data are from Kanton et al. [37]