Table 2 Novel X chromosome lipid-associated loci

rs35143646

2,856,155

T/C

Missense (ARSL)

LDL-C

0.6352

1,038,070

0.0115

(0.0014)

1.83x10^− 16

0.1791

TC

0.6449

1,100,310

0.0091

(0.0014)

1.47x10^− 14

0.08484

nonHDL-C

0.6822

712,983

0.0112

(0.0017)

2.08x10^− 11

0.5294

rs5934507

8,917,206

G/A

Intergenic (FAM9B)

HDL-C

0.274

1,158,000

 − 0.0076 (0.0012)

9.99x10^− 10

5.83x10^− 4

rs191084933

14,133,208

G/A

Intergenic (GEMIN8)

HDL-C

0.0055

1,052,630

0.0694

(0.0101)

5.20x10^− 10

0.3272

rs7888119

16,813,128

T/C

Intronic (TXLNG)

HDL-C

0.546

1,158,000

0.0114

(0.0012)

1.47x10^− 20

0.2212

rs2230488

20,204,461

T/G

Synonymous (RPS6KA3)

LDL-C

0.1772

1,135,110

 − 0.0143 (0.0015)

6.90x10^− 18

0.9297

TC

0.1745

1,237,380

 − 0.0114 (0.0014)

4.68x10^− 12

0.8906

rs6527977

20,322,238

A/C

Intergenic (RPS6KA3)

nonHDL-C

0.1602

789,200

 − 0.0147 (0.0020)

3.06x10^− 10

0.7000

rs12012576

21,813,178

G/A

Intergenic (SMPX)

TG

0.3103

1,160,340

 − 0.0072 (0.0012)

4.88x10^− 8

0.4558

rs6609434

46,636,767

C/A

Intergenic (SLC9A7)

HDL-C

0.4959

767,051

0.0060

(0.0014)

4.25x10^− 8

0.9035

rs113957181

49,848,600

A/C

Intronic (CLCN5)

HDL-C

0.0566

452,268

 − 0.0297 (0.0047)

1.39x10^− 9

0.1896

rs782397956

53,993,589

T/C

Intronic (PHF8)

HDL-C

0.2050

621,342

 − 0.0009 (0.0021)

2.65x10^− 15

0.2585

rs72305711

55,981,911

T/TTA

Intronic (RP13-188A5.1)

HDL-C

0.1111

534,967

 − 0.0167 (0.0033)

2.22x10^− 22

0.03202

rs5914559

56,139,739

G/T

Intergenic (KLF8)

TG

0.6697

738,155

 − 0.0131 (0.0016)

4.44x10^− 16

0.3224

rs5964416

64,368,487

A/C

Intergenic (ZC4H2)

HDL-C

0.0924

614,283

 − 0.0316 (0.0016)

2.68x10^− 11

0.1478

rs5965342

66,204,144

T/C

Intergenic (EDA2R)

HDL-C

0.2037

745,721

 − 0.0212 (0.0020)

1.20x10^− 29

0.02050

rs505520

66,258,914

C/A

Intergenic (EDA2R)

TG

0.2191

750,415

0.0217

(0.0019)

2.91x10^− 30

0.004371

rs771540123

67,967,645

A/G

Intergenic (STARD8)

nonHDL-C

0.0027

15,311

 − 0.0202

(0.115)

1.61x10^− 9

NA

rs5937000

70,047,788

C/T

Intronic (TEX11)

HDL-C

0.4515

796,971

0.0075

(0.0013)

9.55x10^− 9

0.02603

rs5938008

74,496,225

C/T

Intronic (UPRT)

HDL-C

0.9167

1,072,550

0.0174

(0.003)

1.24x10^− 8

0.7235

rs1802288

99,890,204

T/C

Missense (TSPAN6)

LDL-C

0.1665

714,113

0.0159

(0.0019)

1.42x10^− 16

0.9642

TC

0.1684

753,479

0.0128

(0.0018)

2.49x10^− 10

0.8646

rs139144471

117,829,694

G/T

Intergenic (DOCK11)

HDL-C

0.0876

1,098,540

 − 0.0121 (0.0022)

1.16x10^− 8

0.1111

rs6648533

122,804,678

C/T

Intronic (THOC2)

HDL-C

0.299

1,106,090

 − 0.0100 (0.0013)

2.24x10^− 12

0.4516

rs5929738

135,265,287

C/A

Intronic (FHL1)

HDL-C

0.4679

970,330

0.0071

(0.0011)

3.21x10^− 10

0.4197

rs5975692

135,266,089

G/A

Intronic (FHL1)

TG

0.465

1,138,740

 − 0.0084 (0.0011)

7.87x10^− 12

0.9215

rs2070826

153,582,198

C/T

Intronic (FLNA)

HDL-C

0.1427

1,141,020

0.0170

(0.0017)

6.65x10^− 26

0.08671

rs11593

153,627,145

C/A

Intronic (RPL10)

TG

0.1586

1,143,360

 − 0.0166 (0.0017)

5.76x10^− 21

0.8695

rs7886627

153,679,609

G/A

Intergenic (FAM50A)

nonHDL-C

0.1214

771,706

 − 0.0147 (0.0022)

9.26x10^− 9

0.06819

rs1050828

153,764,217

T/C

Missense (G6PD)

LDL-C

0.0113

744,968

 − 0.0514 (0.0061)

2.54x10^− 15

0.6533

rs762517

153,764,734

A/G

Intronic (G6PD)

TC

0.0142

798,600

 − 0.0480 (0.0057)

5.26x10^− 16

0.7594