Table 1 Protective lipid coding alleles associated with CAD and/or T2D

Protective lipid alleles associated with reduced risk of CAD and T2D

 rs116843064

TG

ANGPTL4

p.Glu40Lys

A (0.020)

 − 0.238

0.87

(0.85,0.90)

1.92x10⁻¹⁸

0.91

(0.86,0.95)

2.30x10⁻⁵

0.99

(0.84,1.15)

0.85

 rs1169288

TC

HNF1A

p.Ile27Leu

A (0.682)

 − 0.035

0.97

(0.96,0.98)

2.31x10⁻¹⁶

0.95

(0.94,0.96)

7.30x10⁻¹³

0.95

(0.91,1.00)

0.04

 rs2307111

HDL-C

POC5

p.His36Arg

C (0.440)

0.016

0.99

(0.98,0.99)

9.09x10⁻⁰⁵

0.95

(0.94,0.96)

3.30x10⁻¹⁶

1.00

(0.96,1.05)

0.85

 rs6480771

HDL-C

DUSP13

p.Ser111Gly

T (0.531)

0.008

0.99

(0.98,0.99)

1.44x10⁻⁰⁴

0.97

(0.96,0.99)

4.40x10⁻⁰⁵

0.92

(0.88,0.97)

5.21x10⁻⁰⁴

 rs35742417

TG

RREB1

p.Ser1554Tyr

A (0.173)

 − 0.012

0.98

(0.97,0.99)

5.06x10 ⁻⁰⁴

0.96

(0.95,0.98)

3.70 x10⁻⁰⁶

0.98

(0.93,1.04)

0.60

 rs72681869

TG

SOS2

p.Pro191Arg

C (0.008)

 − 0.053

0.93

(0.89,0.98)

3.71x10⁻⁰³

0.88

(0.82,0.94)

3.90x10⁻⁰⁴

0.87

(0.68,1.12)

0.29

Protective lipid alleles associated with reduced risk of CAD

 rs7412

LDL-C

APOE

p.Arg176Cys

T (0.076)

 − 0.517

0.90

(0.88,0.91)

9.94x10⁻⁵²

1.01

(0.98,1.03)

0.55

1.01

(0.93,1.10)

0.84

 rs11591147

LDL-C

PCSK9

p.Arg46Leu

T (0.015)

 − 0.434

0.80

(0.77,0.83)

5.97x10⁻³⁶

1.04

(0.99,1.09)

0.16

1.05

(0.88,1.26)

0.58

 rs11601507

LDL-C

TRIM5

p.Val112Phe

C (0.926)

 − 0.042

0.95

(0.94,0.96)

2.80x10⁻¹²

0.99

(0.96,1.01)

0.26

1.02

(0.93,1.11)

0.72

 rs1132274

HDL-C

RRBP1

p.Arg891Leu

C (0.827)

0.017

0.97

(0.96,0.98)

3.57x10⁻⁰⁸

1.01

(0.99,1.02)

0.43

1.00

(0.94,1.07)

0.91

 rs4760

HDL-C

PLAUR

p.Leu317Pro

A (0.860)

0.016

0.97

(0.96,0.98)

7.31x10⁻⁰⁷

0.99

(0.97,1.01)

0.3

0.96

(0.91,1.03)

0.26

 rs855791

LDL-C

TMPRSS6

p.Val736Ala

G (0.578)

 − 0.009

0.98

(0.97,0.99)

1.08x10⁻⁰⁶

1.00

(0.99,1.01)

0.75

0.94

(0.9,0.98)

4.83x10⁻⁰³

 rs58542926

TC

TM6SF2

p.Glu167Lys

T (0.073)

 − 0.124

0.97

(0.95,0.98)

4.02x10⁻⁰⁶

1.10

(1.07,1.12)

2.00x10⁻¹⁴

1.45

(1.33,1.58)

1.05x10⁻¹⁶

 rs56196860

HDL-C

FKBP4

p.Asn197Lys

A (0.027)

0.031

0.95

(0.92,0.97)

1.05x10^-05

0.98

(0.94,1.02)

0.33

1.03

(0.87,1.21)

0.73

 rs72836561

HDL-C

CD300LG

p.Arg82Cys

C (0.971)

0.187

0.95 (0.93,0.98)

1.34x10⁻⁰⁴

0.98 (0.95,1.02)

0.4

0.98 (0.86,1.12)

0.77

Protective lipid alleles associated with reduced risk of T2D

 rs1800961

HDL-C

HNF4A

p.Thr139Ile

C (0.969)

0.134

0.99

(0.97,1.01)

0.3751

0.85

(0.82,0.88)

3.20x10^− 20

1.02

(0.90,1.17)

0.74

 rs1801253

TG

ADRB1

p.Gly389Arg

C (0.732)

 − 0.011

1.01

(1.00,1.02)

8.76x10^− 03

0.97

(0.96,0.98)

1.9010x^− 05

1.00

(0.95,1.06)

0.85

 rs13107325

HDL-C

SLC39A8

p.Ala391Thr

C (0.941)

0.082

1.00

(0.98,1.01)

0.8876

0.95

(0.93,0.98)

3.30Ex10^− 04

0.85

(0.78,0.93)

1.85x10^− 04