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Fig. 3 | Genome Biology

Fig. 3

From: Distance-dependent inhibition of translation initiation by downstream out-of-frame AUGs is consistent with a Brownian ratchet process of ribosome scanning

Fig. 3

The reduction in the mRNA level caused by proximal out-of-frame dATGs, via the NMD pathway. A The experimental procedure for high-throughput determination of the mRNA levels for individual variants in the dATG library. B, C The average mRNA levels (dots) and the 95% confidence intervals (error bars) of Duo variants, in the background of hoΔ (B) and upf1Δ (C), grouped by the sequence contexts of the dATG (letters in red). Data from the two biological replicates were combined. The numbers of N-context Solo variants are 1805 (hoΔ) and 1989 (upf1Δ)

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Genome Biology

ISSN: 1474-760X

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