Fig. 2

Genetic influences on CoRSIV methylation are strong and biased. A, B Representative plots of mQTL associations at individual CoRSIVs on chromosomes 1 and 2, respectively. Significant associations are shown for all SNVs within 1Mb of each CoRSIV; positive and negative beta coefficients are plotted in blue and red, respectively. The most significant SNV (Simes SNV) is circled. Insets show average CoRSIV methylation vs. Simes SNV genotype. C Distribution of distances between CoRSIVs and corresponding Simes SNVs. D For each of 4086 CoRSIVs, heat map depicts the number of tissues in which the Simes SNV falls within the same haplotype block, illustrating the largely systemic nature of mQTL at CoRSIVs. E Distribution of beta coefficients of significant Simes mQTL associations for the GoDMC blood mQTL data [42]. F Distribution of beta coefficients of significant Simes mQTL associations at 3723 CoRSIVs in blood DNA from 188 GTEx donors. G Distribution of beta coefficients of significant Simes mQTL associations across 2939 CoRSIVs in blood DNA from 47 newborns (USC). H Distribution of Simes mQTL R² (goodness of fit) for the GoDMC data. I Distribution of Simes mQTL R² at CoRSIVs (GTEx, blood). J Distribution of Simes mQTL R² at CoRSIVs (USC samples)