Clustering Deviation Index (CDI): a robust and accurate internal measure for evaluating scRNA-seq data clustering

Table 3 Clustering method summary

Clustering method	Description	Reference
Hierarchical clustering	Bottom-up procedure to merge closest cells; complete linkage	[3]
K-means	Identify k-centers minimizing the within-cluster sum of squares	[2, 3]
Spectral clustering	Graph-based algorithm: eigenvectors of affinity matrix	[54]
CIDR	Dropout identification\(+\)PCA\(+\)hierarchical clustering	[5]
SC3	Consensus clustering (distance and correlations++PCA and Laplacian++K-means)	[10]
Seurat v3	PCA\(+\)Graph-based algorithm	[8]

ISSN: 1474-760X