Skip to main content
Fig. 2 | Genome Biology

Fig. 2

From: Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum

Fig. 2

Upregulation of PSGs in tumors. a Distribution of the median log2(Fold change) of 423 PSGs across tumors. Tumor types are sorted by decreasing values. b Distribution of the ssGSEA enrichment scores of PSGs across tumor types. For each violin plot, the bar, the line, and the curve indicate the interquartile range, the median, and the probability density of the data, respectively. The median score of PSGs in normal samples was set as 0, i.e., the normal median was subtracted from its counterpart in tumor samples. Tumors are sorted by decreasing scores. c Violin plots showing distributions of enrichment scores (median across tumors) of genes within 14 age groups. For each group (defined as in Fig. 1b), the median enrichment score was calculated separately for normal and tumor samples within each tumor type. Similar to Panel b, the median values in normal samples were set as 0. d Enrichment score-based expression patterns of broadly transcribed PSGs and tissue-biased PSGs across tumors. e Proportion comparison between pan-cancer upregulated and downregulated genes. A one-sided Wilcoxon signed-rank test was used for panels a–d and a one-sided binomial test was used for panel e. Multiple testing correction was performed via false discovery rate (FDR)

Back to article page