Fig. 1

Number of de novo mutations and mutation rates among 68 individuals. A The number of de novo STR mutations identified in each individual from the second generation of the CEPH pedigrees. The mean number of identified mutations was ~ 42, with wide variation in the number of de novo mutations detected per individual. B The STR mutation rate for each individual in the second generation of the CEPH pedigrees. C The majority of de novo STR mutations were identified in intergenic regions (shown in green) and intronic regions (shown in yellow). Only two mutations overlap with exons. D Mutation rates for 2747 unique genotyped short tandem repeats with motif lengths from 1 bp (mononucleotide) to 6 bp (hexanucleotide). Mutation rates generally decrease as motif length increases, with some exceptions