Fig. 5

Using MoDLE to predict effects of deletions to TAD borders in the HoxD locus. A Micro-C data in JM8.N4 mESC WT cells showing the interactions surrounding the HoxD cluster and the centromeric (C-DOM) and telomeric (T-DOM) domains in a non-mutated wildtype (WT) condition. B MoDLE output from the same region in the WT condition. C MoDLE output produced with a partial deletion of the border between the domains. D MoDLE output with a complete deletion of the border between the domains. E Differential contact map showing the ratio of MoDLE (WT condition; B) vs. MoDLE (full deletion, D). Regions enriched in MoDLE full deletion are shown in red, whereas regions enriched in MoDLE WT are shown in blue