Fig. 3

Results of phylogenetic inference and variant calling for the CRC28 dataset. Shown is SIEVE’s maximum clade credibility tree. The exceptionally long trunk has been folded (marked by slashes). Cells are coloured according to the corresponding biopsies. The numbers at each node represent posterior probabilities (threshold \(p > 0.5\)). At each branch, genes with non-synonymous mutations are depicted in blue. a, b Variant calling heatmap for SIEVE (a) and Monovar (b). Listed in the legend are the categories of predicted genotypes by each method. Cells in the row are in the same order as that of leaves in the phylogenetic tree