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Fig. 1 | Genome Biology

Fig. 1

From: Lineage abundance estimation for SARS-CoV-2 in wastewater using transcriptome quantification techniques

Fig. 1

VLQ, a computational approach to lineage abundance estimation from wastewater sequencing data. a Computational similarity between RNA transcript quantification and lineage abundance estimation. b Key aspects of the kallisto algorithm in the context of lineage abundance estimation. c Our workflow uses multiple reference sequence per lineage to capture within-lineage variation. Applying kallisto (as in part b) results in abundance estimates per reference sequence. These abundances are filtered using a minimal abundance cutoff and subsequently summed per lineage to obtain abundance estimates per lineage. Finally, lineage abundances are reported

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