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Fig. 2 | Genome Biology

Fig. 2

From: Deciphering the impact of genetic variation on human polyadenylation using APARENT2

Fig. 2

Prediction of functionally screened polyadenylation variants. A Variant of uncertain significance from ClinVar (rs886052699) measured in an MPRA [36]. Shown are the measured and predicted 3′ cleavage distributions across the PAS. Green: wildtype cleavage, magenta: variant cleavage. B Comparison of precision-recall curves when tasking each APA model with classifying disruptive APA variants (\(|\text {fold change}| > 2\)) from the MPRA of Bogard et al. [36] (n = 12,350). The curves are shown for non-CSE variants only. C Comparison of predicted vs measured RNA/DNA log fold change ratios on the data from Slutskin et al. [35] (n = 442). D Comparison of predicted vs measured RNA/DNA log fold change ratios at individual cleavage sites within a given PAS

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