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Fig. 6 | Genome Biology

Fig. 6

From: Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3′ untranslated region

Fig. 6

Multifactorial genetic model for overweight and obesity risk. A Multifactorial model to predict body mass index (BMI). Estimated parameters and 95% CI, plus p-values of variables in the multifactorial model. The linear regression model included the rs2291007 SNP (in additive form), three gene expression variables (FNIP2, FNIP1, and FLCN), plus sex, age, and the interaction between FNIP2 gene expression and rs2291007. B Bootstrap validation of the multifactorial model. Multifactorial model was validated through bootstrap validation, using 2000 bootstrap samples, which correction by optimism (MSE, Mean Square Error). C Variable importance plot for the multifactorial model, using χ2 – df (degrees of freedom) as metrics for the importance of each variable

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Genome Biology

ISSN: 1474-760X

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