Fig. 3

Transcriptomic consequences of rs2291007. A Box plot of the association between gene expression level for FNIP2 and genotype for rs2291007. The box plot shows how the FNIP2 expression values are distributed for each genotype from recessive model of inheritance in COSMIC cell lines. Common/major Homozygous plus Heterozygous alleles (C/C + C/T); Variant/minor Homozygous allele (T/T). Differences between gene expression in two groups were tested through Student’s t test. B Box plot of the association between gene expression level for FNIP2 and genotype for rs2291007 in 161 healthy volunteers. The 2^−ΔΔCt method was applied to calculate the relative gene expression. Differences between gene expression in two groups were tested through Student’s t test and through linear models with adjustment variables. C Associations of FNIP2 expression and phenotypic characteristics related to metabolism and obesity in 161 healthy volunteers. Differences between gene expression in two groups were tested through linear models with adjustment variables. All tests were bilateral. Ninety-five percent confidence intervals were used in beta estimates. Bonferroni method was applied for multiple-test correction of all p-values. D Associations of FLCN expression and phenotypic characteristics related to metabolism and obesity in 161 healthy volunteers. Differences between gene expression in two groups were tested through linear models with adjustment variables. All tests were bilateral. Ninety-five percent confidence intervals were used in beta estimates. Bonferroni method was applied for multiple-test correction of all p-values