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Table 1 Comparison of existing APA methods and ReadZS

From: ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq

Method

Sierra [16]

MAAPER [17]

scDaPars [15]

ReadZS

Single-cell resolved (no pseudobulking)

No

No

Yes

Yes

Imputation-free

Yes

Yes

No

Yes

Does not require gene annotations

No

No

No

Yes

Does not require peak calling

No

No

No

Yes

Can be used with continuous metadata, e.g., pseudotime

No

No

No

Yes