Fig. 4

Event detection for the Gundem et al. [40] cohort. a WGD detection. In the 10 patients, a total of 4 WGDs were detected, two of which were clonal, one subclonal and one in a terminal branch. b Distribution of arm-level events. Using the MEDICC2 event detection routine, we detected the number of times a whole chromosome arm was either gained or lost in a single branch. The gains and losses were aggregated over all patients and samples into a single score. This score was compared against the oncogene - tumor suppressor gene (OG-TSG) score derived by Davoli et al. [41]. A clear correlation between the gains/losses and the OG-TSG score (which is not based on copy numbers) is visible. c Distribution of gene-level events. The analysis was repeated on the basis of all 1729 individual genes present in the Davoli et al. dataset. On the x-axis, we plotted the base-10 logarithm of the genes’ p-values and flipped the sign for the oncogenes to create a single, continuous x-axis for both genesets. A small correlation is visible which becomes more pronounced when only considering the top 100 genes. Names are given for genes with p < 10⁻²⁰