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Fig. 3 | Genome Biology

Fig. 3

From: Significant variation in the performance of DNA methylation predictors across data preprocessing and normalization strategies

Fig. 3

Pipeline performance impacts downstream analyses of DNAm age predictors. Shown are the association between pipeline ICC and the correlation with chronological age (left panels), the hazard ratio of mortality risk prediction (middle panel), and the z-score of the mortality risk prediction (right panels) for HorvathAge (top row), PhenoAge (2nd row), GrimAge (3rd row), and ZhangAge (bottom row). Pipelines are color-coded by package/method. Spearman rank correlation statistics are shown in the top left corners

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