Fig. 6
From: Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
Local CpG density affects the trajectory of age-associated epigenetic changes. We propose that collaborative interactions between CpGs reinforce maintenance of methylation patterns in CpG dense regions (a). These interactions are weaker in CpG-poor regions leading to the degradation of methylation patterns with time and emergence of variation. These interactions can also be altered by SNPs leading to differences in epigenetic trajectories between individuals who inherit different alleles (b)