Fig. 2
From: Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
A subset of CpGs gain methylation in later life. a A subset of CpGs gain methylation in LBC. Histogram of the mean methylation trajectories for the 182,760 CpGs whose slope significantly deviates from 0 (T-test, Bonferroni-corrected p < 0.01). b Example of a rapid gain CpG. Individual methylation trajectories are indicated by gray lines. The mean methylation trajectory is indicated by the bold line and the dashed lines are the 95% confidence intervals. c Rapid gain CpGs are depleted from CGIs and enriched in gene bodies and intergenic regions. Barplot showing the % fold change observed for rapid gain CpGs in different genome annotations versus the background of all analyzed CpGs. P-values are from 2-sided Fisher’s exact tests. PMDs = partially methylated domains; HMDs = highly methylated domains. d Rapid gain CpGs are enriched in transcription and heterochromatin states in GM12878 cells. Barplot showing the % fold change observed for rapid gain CpGs in different chromatin states in GM12878 cells versus the background of all analyzed CpGs. Shown are significant P-values from 1-sided Fisher’s exact tests