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Fig. 1 | Genome Biology

Fig. 1

From: Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

Fig. 1

Longitudinal methylation trajectories reveal changes at individual epigenetic clock loci. a ELOLV2 shows increases in methylation across individuals. Plots of methylation levels at ELOVL2 CpG cg16867657 showing data from one individual in the cohort and their methylation trajectory (left and middle panel, red points and line), and methylation trajectories for all individuals (right panel, gray lines). In the right panel, the bold line indicates the mean methylation trajectory, and the dashed lines are the 95% confidence intervals. b Examples of methylation trajectories observed for epigenetic clock CpGs. Individual methylation trajectories are indicated by gray lines. The mean methylation trajectory is indicated by the bold line and the dashed lines are the 95% confidence intervals. c Methylation trajectories recapitulate the predicted behavior of epigenetic clock CpGs. Boxplots showing the calculated mean rates of change for CpGs that are part of the Hannum or Horvath epigenetic clocks split by their reported direction of change. P-values were calculated using T-test. Lines = median; Box = 25th–75th percentile; whiskers = 1.5 × interquartile range from box; n indicates the number of CpGs in each group

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