Table 1 Summary of complex traits/diseases and implicated tissues
Trait/disease name | Abbr | Year | # samples | Implied tissue | pBH(deTS) |
|---|---|---|---|---|---|
Alcohol use disorder [22] | AUD | 2019 | 202,004 | Brain—cerebellum | 0.08 |
Alzheimer’s disease [23] | AD | 2018 | 455,258 | Whole blood | 9.94 × 10−9 |
Amyotrophic lateral sclerosis [24] | ALS | 2016 | 36,052 | Heart—atrial appendage | 0.28 |
Anxiety, anxiety-continuous [25] | ANX | 2016 | 18,186 | Brain—spinal cord (cervical c-1) | 0.10 |
Anxiety tension-special-factor-of-neuroticism[26] | ANEU | 2019 | 270,059 | Brain—anterior cingulate cortex (BA24) | 6.49 × 10−3 |
Asthma [27] | Asthma | 2017 | 127,669 | Spleen | 9.71 × 10−3 |
Attention-deficit-hyperactivity disorder [28] | ADHD | 2017 | 53,293 | Brain—anterior cingulate cortex (BA24) | 9.05 × 10−4 |
PGC Autism, Autism-Europeans [29] | ASD | 2017 | 13,574 | Heart—atrial appendage | 0.40 |
Bipolar disorder [30] | BD | 2018 | 51,710 | Brain—anterior cingulate cortex (BA24) | 6.85 × 10−4 |
Blood lipids, high-density lipoprotein [31] | HDL | 2010 | 99,900 | Liver | 6.62 × 10−4 |
Blood lipids, low-density lipoprotein [31] | LDL | 2010 | 95,454 | Liver | 2.11 × 10−8 |
Blood lipids, total cholesterol [31] | TC | 2010 | 100,184 | Liver | 6.91 × 10−10 |
Blood lipids, triglycerides [31] | TG | 2010 | 96,598 | Liver | 1.31 × 10−8 |
Body mass index [32] | BMI | 2015 | 234,069 | Colon—sigmoid | 0.02 |
CAD resting heart rate [33] | CAD_RHR | 2016 | 265,046 | Liver | 4.80 × 10−3 |
Coronary artery disease [34] | CAD | 2017 | 63,731 | Artery—aorta | 0.01 |
Depressive symptoms [35] | DS | 2019 | 181,045 | Adrenal gland | 0.18 |
Educational attainment, education years all [36] | EDU | 2016 | 293,723 | Brain—frontal cortex (BA9) | 3.31 × 10−4 |
General factor of neuroticism [26] | GNEU | 2019 | 270,059 | Brain—nucleus accumbens (basal ganglia) | 3.10 × 10−5 |
Heart failure [37] | HF | 2018 | 394,156 | Artery—aorta | 0.19 |
Height [38] | Height | 2014 | 253,288 | Artery—tibial | 0.02 |
Internalizing problems [39] | IP | 2014 | 4596 | Adrenal gland | 0.44 |
Lipoprotein concentrations, HDL [40] | LIP_HDL | 2009 | 19,840 | Adipose—visceral (omentum) | 0.03 |
Lung function, FEV1/FVC [41] | FEV1 | 2019 | 316,614 | Artery—tibial | 1.52 × 10−5 |
Lung function, FVC [41] | FVC | 2019 | 317,222 | Colon—sigmoid | 1.04 × 10−3 |
Major depressive disorder [42] | MDD | 2018 | 42,455 | Brain—anterior cingulate cortex (BA24) | 0.04 |
Multiple sclerosis [43] | MS | 2018 | 41,505 | Spleen | 9.03 × 10−15 |
Neuroticism [35] | NEU | 2019 | 523,783 | Brain—cerebellar hemisphere | 9.18 × 10−3 |
Obsessive–compulsive disorder [44] | OCD | 2017 | 9,725 | Brain—cerebellum | 0.05 |
Pancreatic cancer [45] | PanCan | 2009 | 3,576 | Adipose—subcutaneous | 0.73 |
Parkinson’s disease [46] | PD | 2012 | 8,477 | Brain—cerebellum | 3.65 × 10−4 |
Resting heart rate [47] | RHR | 2019 | 458,969 | Heart—atrial appendage | 9.27 × 10−17 |
Rheumatoid arthritis [48] | RA | 2014 | 58,284 | Spleen | 2.80 × 10−10 |
Schizophrenia [49] | SCZ | 2018 | 74,626 | Brain—frontal cortex (BA9) | 6.60 × 10−3 |
SSGAC College [50] | COL | 2013 | 101,069 | Brain—cerebellar hemisphere | 2.76 × 10−3 |
Subjective wellbeing [51] | SWB | 2016 | 298,420 | Brain—amygdala | 0.20 |
Type 2 diabetes [52] | T2D | 2017 | 159,208 | Brain—spinal cord (cervical c-1) | 0.10 |
Type 1 diabetes [53] | T1D | 2011 | 26,890 | Spleen | 8.64 × 10−9 |
Type 1 diabetes, childhood adiposity age under17 [54] | T1D_C | 2017 | 14,741 | Spleen | 7.61 × 10−10 |
Waist format 2: Waist hip ratio [55] | WHR | 2015 | 143,480 | Esophagus—Muscularis | 0.04 |