Fig. 2
From: Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice
Positively selected genes (PSGs) associated with domestication in mice. a The diagram of domestication history of classical inbred mice and the strategy for selecting PSGs. b–d Manhattan plots indicate high and low positive selected regions by nucleotide diversity (πwild/πclassical_inbred), Fst, and XP-CLR. The highly selected genes marked by gray lines are individually validated by the following experiments. e The Venn diagram depicting genes identified by three independent approaches illustrated in b–d. The intersection includes finally selected 339 PSGs. f The ratios of highly expressed genes in the 339 PSGs are disproportionally enriched in brain. “Immature brain” indicates all the average RPKM of embryonic central neuro system tissues aged 11.5, 14, and 18 days post coitum; “Brain” indicates all the average RPKM of the adult brain tissues cerebellum, cortex, and frontal lobe