Fig. 1
From: Genomics and epigenetics guided identification of tissue-specific genomic safe harbors
A schematic representation of the overall genomic safe harbor identification strategy. a Selection of common pMEIs from healthy individuals with AF > 0.1. b Removing pMEIs significantly associated with gene expression (FDR < 0.1 in eQTL mapping). c Removing pMEIs showing spatial proximity with oncogenes, tumor suppressor genes, and dosage-sensitive genes based on TADs and chromatin interaction mapping. d Removing pMEIs overlapping repressive chromatin regions