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Fig. 8 | Genome Biology

Fig. 8

From: DNA methylation underpins the epigenomic landscape regulating genome transcription in Arabidopsis

Fig. 8

Function of DNA methylation in histone modification and transcription landscapes. a Distinct models of DNA methylation in regulating H3K9me2. (1) A feedback loop between non-CG methylation and H3K9me2: non-CG methylation recruits the H3K9 methyltransferases SUVH4, SUVH5 and SUVH6, and in turn, H3K9me2 facilitates CMT3 and CMT2 function to methylate CHG and CHH; (2 and 3) most of H3K9me2 is regulated by CG methylation (2) or by both CG and non-CG methylation (3), through yet unclear mechanisms. mCG, methylated CG; mNon-CG, methylated non-CG including methylated CHG and CHH. b Representative models for the impacts of DNA methylation on histone modifications and TE/gene transcription. Descriptions are in main text

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