Fig. 4

Receiver operator characteristic (ROC) curves for different polygenic risk scores. A–C Ability of PRS to distinguish between cases and controls (European and African data). D–F Ability of PRS to distinguish between cases that have aggressive and non-aggressive forms of CaP (African data). CaP was classified as aggressive if tumor stage = T4 (opposed to T1, T2, or T3) or Gleason score ≥ 8 (as opposed to Gleason score ≤7), and separate analyses were run for each classifier