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Fig. 5 | Genome Biology

Fig. 5

From: Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Fig. 5

Schematic representation of events that best explain the segregation of a zygote into biparental and androgenetic (A, B) or androgenetic and gynogenetic blastomeres (C). Curved arrows depict replication of the genome. In A, extrusion of paternal genome(s) is depicted following polyspermic fertilization. In some embryos, this event occurred in parallel with the replication and karyokinesis of the primary maternal and paternal genome. In E06 and E12, some of the parental genomes were replicated but failed to undergo karyokinesis. In B, segregation of an additional paternal genome occurs through a second, paternally organized spindle. In E15, a third paternal genome was protruded to one of the androgenetic blastomeres and genome-wide chromosomal losses occurred on one paternal genome (yellow stars). In C, private parental spindles are established around the maternal and the paternal genomes (E25) following polyspermic fertilization, or only around the maternal genome following normal fertilization (E23). In E23, the paternal genome is extruded in a separate blastomere

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