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Fig. 2 | Genome Biology

Fig. 2

From: Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

Fig. 2

DNMT1 is required for the repression of pluripotency and extra-embryonic programmes and for the up-regulation of posterior Hox genes. a Polar bar plots display the number of differentially expressed genes in Dnmt1-/- cells, split by whether genes are downregulated (left) or upregulated (right). Each bar corresponds to a different cell type. Shown are all Hox genes (top) primed pluripotency markers (middle) and markers of extra-embryonic (ExE) tissues (bottom), according to the reference atlas. b Heatmaps display the log fold change in gene expression between mutant and wildtype. Shown are Hox genes (top), primed pluripotency markers (middle) and markers of ExE lineages (bottom). c Gene expression levels quantified at the pseudobulk level, where each data point corresponds to a different embryo and cell type. Shown are Hox genes (top), primed pluripotency markers (middle) and ExE tissue markers (bottom)

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