Skip to main content
Fig. 1 | Genome Biology

Fig. 1

From: The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

Fig. 1

ZCWPW1 is required for H3K9ac modification of recombination hotspots during male meiosis. a The genome browser view of DMC1 and ZCWPW1 signals in WT mouse testes and the H3K9ac signal in WT, Spo11–/–, Prdm9–/–, and Zcwpw1–/– testes. H3K9ac peaks overlapping hotspot sites are indicated by orange shaded areas, while H3K9ac peaks at promoter regions are indicated by blue shaded areas. b Heatmap showing the ZCWPW1 and DMC1 signals in WT testes and the H3K9ac signal in WT, Spo11–/–, Prdm9–/–, and Zcwpw1–/– testes at two distinct groups of ZCWPW1 binding sites (peaks). Group H1 represents those ZCWPW1 binding sites that lost the H3K9ac signal in Zcwpw1–/– testes, and group H2 represents those ZCWPW1 binding sites that retained the H3K9ac signal in Zcwpw1–/– testes. The regions of group H1 or H2 in heatmaps were ordered from largest to smallest based on the average signal in all samples

Back to article page