Fig. 4From: CTCF and cohesin promote focal detachment of DNA from the nuclear laminaCohesin dynamics affect chromosomal NL interaction patterns. A Quantification of the LAD differences in LaminB1 z-scores over time (Additional file 1: Fig. S7). The standard deviation is included. Changes that exceed the distribution observed for the PT 24 h control (beyond 0.1% and 99.9% of the data points) are classified as different. B Fraction of the LADs classified as different. The actual number of LADs is included. C Heatmap showing Spearman correlation coefficients between the LAD differences following auxin addition. LAD differences from the same depletion experiment are not independent as these compare differences relative to the same starting point, and are thus inflated. D Heatmap showing Spearman correlation coefficients between LAD features (Additional file 1: Fig. S8) and differences in LAD scores. Non-significant correlation (p > 0.05, using “cor.test()” in R) after Benjamini–Hochberg multiple testing correction is in gray. The LAD features are defined as follows: LAD size (log2 bp), CTCF binding and active gene density (count/Mb), average H3K27me3 and H3K9me2 signal, local LAD density (fraction of the surrounding 30 Mb classified as LAD), distance to chromosome ends (Mb), and size of the corresponding chromosome (Mb). E Scatterplots of LAD differences over time versus LAD size (top panels) and distance to telomere (bottom panels), colored by chromosome. The black line represents a fitted linear modelBack to article page