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Fig. 3 | Genome Biology

Fig. 3

From: Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHin

Fig. 3

Meta-analytic omnibus and per-feature testing reveal novel and previously documented IBD associations. a Omnibus testing (PERMANOVA on Bray-Curtis dissimilarities with stratification and covariate control where appropriate, see “Methods” and Additional file 5: Table S3) identified between-subject differences as the greatest source of microbiome variability, with IBD phenotype, disease (CD/UC), and sample type (stool/biopsy) as additional main sources of biological variation. MMUPHin successfully reduced between-cohort and within-study batch effects, although these technical sources also remained significant contributors to variability. b Individual taxa significantly associated with IBD phenotypes or treatments after meta-analysis. Taxa are arranged by family-level median effect size of IBD vs. control for disease results and that of antibiotic usage for treatment results. Effect sizes are aggregated regression coefficients (across studies with random effects modelling) on arcsin square root-transformed relative abundances. Detailed model information in “Methods” and Additional file 5: Table S3. Individual study results in Additional file 6: Table S4

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