Table 3 Ontology enrichment of proteomics data

Dataset

Pathways

1: WikiPathways 2019 (human)

2: KEGG 2019 (human)

Ontology

[biological process]

Regulators

1: ChEA 2016

2: TTRUST 2019

3: ENCODE 2015

Adipose:

early-HD vs. control

1: Blood clotting cascade (1480.08), statin pathway (408.90), proteasome degradation (378.24)

2: Complement and coagulation cascades (546.42), proteasome (225.26), cholesterol metabolism (195.08)

Chylomicron remodeling (2106.52), nitric oxide-mediated signal transduction (1008.13), fibrinolysis (921.53), proteasomal ubiquitin-independent protein catabolic process (528.58), interleukin-1-mediated signaling pathway (209.32)

1: HNF4A (14.55), AR (13.99), NANOG (13.59)

2: PPARA (273.66)

3: FOXA2 (29.83), NR2C2 (25.90), HNF4G (24.99)

Skin:

early-HD vs. control

1: Translation factors (337.17), mRNA processing (261.60), methylation pathways (234.97)

2: Spliceosome (298.11), arginine biosynthesis (167.83), tyrosine metabolism (72.16)

Protein localization to cytoplasmic stress granule (356.98), mRNA splicing, via spliceosome (343.79), IRES-dependent viral translational initiation (198.37), aspartate family amino acid metabolic process (198.37), nucleoside metabolic process (198.37)

1: XRN2 (23.62), AR (23.21), TP63 (22.90)

2: BRCA1 (34.50), VDR (21.17), AR (14.95)

3: NELFE (93.56), KAT2A (74.77), TAF7 (48.19)

Skin:

early-HD vs. pre-HD

1: Extracellular vesicle-mediated signaling in recipient cells (1346.70), ErbB signaling pathway (298.26), AGE/RAGE pathway (176.44)

2: ErbB signaling pathway (327.55), oxytocin signaling pathway (295.74), neurotrophin signaling pathway (205.61)

Cargo loading into COPII-coated vesicle (1787.10), ERBB2 signaling pathway (942.71), ephrin receptor signaling pathway (130.95), Fc receptor signaling pathway (111.42), mRNA splicing, via spliceosome (65.83)

1: SOX11 (22.22), EGR1 (22.10), FOXP2 (19.42)

2: TP53 (130.54), SP1 (9.04)

3: TEAD4 (60.02), GTF3C2 (23.76), SP2 (20.43)