Fig. 1From: Prediction of evolutionary constraint by genomic annotations improves functional prioritization of genomic variants in maizeDistribution of rejected substitution (RS) scores by category of DNA bases. RS scores, which integrate information about conservation (1 − Substitution rate) and MSA depth (Tree size), were calculated by gerp++ [4] as previously described [14]. Monomorphic sites: sites with no observed polymorphism within maize. SNPs: observed polymorphisms in Hapmap 3.2.1, a representative panel of inbred lines in maize [15]. SNPs in hybrid panels: subset of SNPs which are observed in two panels of hybrid crosses between inbred lines and testers [16]Back to article page